عنوان

بررسی متقاطع با کنترل دارونما درمورد تاثیرافزودن دونپزیل به داروهای ضدروانپریشی اتیپیک دربهبود علائم مثبت و منفی وآسیب شناسی روانی عمومی اسکیزوفرنیا

IR

۱۳۴۸پ

فارسی

IR

بررسی متقاطع با کنترل دارونما درمورد تاثیرافزودن دونپزیل به داروهای ضدروانپریشی اتیپیک دربهبود علائم مثبت و منفی وآسیب شناسی روانی عمومی اسکیزوفرنیا

[پایان‌نامه]

. Intersecting study with placebo-Controlled on the offect of adding Donepenzil to anti-psychotic durg in improving of possitive & negative symptoms of schizophrenia public pathology

علوم بهزیستی وتوانبخشی university of social welfare and rehabilitation))

، ۱۳۸۸

۶۹ص.

پیوست

چاپی

دکترا

روانپزشکی psychiatry

علوم بهزیستی وتوانبخشی university of social welfare and rehabilitation))

Rational : Schizophrenia is one of the most common chronic mental disorders in all human societies .Age sex race and social class doesnt limit it .It usually involves young patients and sometimes stand in all of the patients life time .Usually large burden of disorder adds to health system due to diagnosis treatment rehabilitation and caring of these patients. Despite of good results in treatment of psychotic symptoms of these patients the main effects of these drugs are on the positive symptoms of schizophrenia. These drugs ( antipsychotics ) minimized severity of delusions and hallucinations or inhibited of them they decrease irritable mood bizarre and aggressive behaviors of schizophrenic patients .Most of these drugs have little effects on withdrawal apathy or other negative symptoms of schizophrenic patients . Therefore finding of other ways for improvement of schizophrenic patients is one of the most important problems of mental health . Method: We conducted at 14wk double blind crossed over Trial of Donepezil at doses of 5 mg /day or placebo for 6 weeks Added to ongoing atypical antipsychotic in 24 stable Schizophrenic In patients who were diagnosed according to DSM IV TR criteria and had been on a stable dose of a high potency atypical antipsychotic for a minimum period of 3 months After a two week wash out period they crossed over to the alternate condition for additional 6 weeks. At baseline 6 and 14 week patient were evaluated with the positive and Negative syndrome scale ( PANSS ) Result : All the data were analyzed with both repeated measurment analysis of variences And paired T test. Negative subscale of PANSS improved by Donepezil in group 2 It was statistically significant (pvalue=0/47). Donepezil increased numerically the positive sub Scale of PANSS in both group but it was not significant statistically. Conclusion: in summary our study high lights the sufficiency of CEI in improving negative symptoms in schizophrenia .Statistically significant improvement in PANSS results can be a rational for adding a cholinesterase inhibitors to antipsychotics in schizophrenia. Larger trials with sufficient duration are needed to resolve this issue .

ba

. Intersecting study with placebo-Controlled on the offect of adding Donepenzil to anti-psychotic durg in improving of possitive & negative symptoms of schizophrenia public pathology

Schizophrenia

اسکیزوفرنیا

Schizophrenia

طیبی، افشین

Tayebi, Afshin

فدایی، فربد

نیکنام، زهرا

ایران

دانشگاه علوم توان بخشی و سلامت اجتماعی

1348..pdf

محرمانه

محرمانه

13481.pdf

1391557

مرجع

متن

0

۸۴۳۱پایا

محل نگهداری: دانشگاه علوم بهزیستی وتوانبخشی

نمایه‌سازی قبلی

چاپی-الکترونیکی

TF

1

a

Y