عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
شماره کتابشناسی ملی
شماره
TLpq304481918
زبان اثر
زبان متن نوشتاري يا گفتاري و مانند آن
انگلیسی
عنوان و نام پديدآور
عنوان اصلي
A test of the serotonin hypothesis of nonphotic phase shifting of the Syrian hamster circadian system
نام عام مواد
[Thesis]
نام نخستين پديدآور
M. C. Antle
نام ساير پديدآوران
R. E. Mistlberger
وضعیت نشر و پخش و غیره
نام ناشر، پخش کننده و غيره
Simon Fraser University (Canada)
تاریخ نشرو بخش و غیره
1998
مشخصات ظاهری
نام خاص و کميت اثر
89
یادداشتهای مربوط به پایان نامه ها
جزئيات پايان نامه و نوع درجه آن
M.A.
کسي که مدرک را اعطا کرده
Simon Fraser University (Canada)
امتياز متن
1998
یادداشتهای مربوط به خلاصه یا چکیده
متن يادداشت
In the Syrian hamster, the daily rhythm of activity can be reset by activity experimentally induced during the mid-day, which is the usual rest phase in nocturnal rodents. These non-photically induced phase shifts may be mediated, in whole or in part, by serotonergic input to the circadian pacemaker, located in the suprachiasmatic nuclei (SCN). This hypothesis is based on evidence that serotonin agonists can phase shift behavioural rhythms in vivo, and SCN electrophysiological rhythms in vitro. However, evidence that serotonin lesions or antagonists can prevent activity-induced phase shifts is weak or lacking. The present experiment was designed to further test this serotonin hypothesis of non-photic entrainment. Hamsters were given 3 hour wheel confinement tests, to induce activity, following treatment with various selective and non-selective serotonin antagonists, or their vehicles, delivered synthetically or centrally. Metergoline, WAY100135, and Ritanserin did not attenuate the resulting phase shifts from induced activity. NAN190 did significantly attenuate the resulting phase shift, but this effect was confounded with an attenuation of the induced activity. This study failed to support the position that serotonergic activity within the SCN is necessary for the production of non-photic phase shifts. The receptor ligands selected are active primarily at 5-HT1A/7 receptors, as previous studies suggest that these are the most likely receptors to mediate phase shifting of the SCN pacemaker by serotonin. However, it remains possible that a novel type of serotonin receptor may mediate the effects of serotonin and behavioral stimuli on circadian phase.
موضوع (اسم عام یاعبارت اسمی عام)
موضوع مستند نشده
Anatomy & physiology
موضوع مستند نشده
Animals
موضوع مستند نشده
Biological sciences
موضوع مستند نشده
Health and environmental sciences
موضوع مستند نشده
Neurology
موضوع مستند نشده
Pharmacology
نام شخص به منزله سر شناسه - (مسئولیت معنوی درجه اول )
مستند نام اشخاص تاييد نشده
M. C. Antle
مستند نام اشخاص تاييد نشده
R. E. Mistlberger
دسترسی و محل الکترونیکی
نام الکترونيکي
مطالعه متن کتاب وضعیت انتشار
فرمت انتشار
p
اطلاعات رکورد کتابشناسی
نوع ماده
[Thesis]
کد کاربرگه
276903
اطلاعات دسترسی رکورد
سطح دسترسي
a
تكميل شده
Y
