عنوان

Bioactive secondary metabolites from marine algae and study of oxidized anandamide derivatives

شماره

TLpq304384755

زبان متن نوشتاري يا گفتاري و مانند آن

انگلیسی

عنوان اصلي

Bioactive secondary metabolites from marine algae and study of oxidized anandamide derivatives

نام عام مواد

[Thesis]

نام نخستين پديدآور

H.-D. Yoo

نام ناشر، پخش کننده و غيره

Oregon State University

تاریخ نشرو بخش و غیره

1997

نام خاص و کميت اثر

148

جزئيات پايان نامه و نوع درجه آن

Ph.D.

کسي که مدرک را اعطا کرده

Oregon State University

امتياز متن

1997

متن يادداشت

My investigations of the natural products of marine algae have resulted in the discovery of several new secondary metabolites. Bioassay-guided fractionation led to the isolation of these new compounds and spectroscopic analysis was utilized in their structural characterization. Two new and potent antimitotic metabolites, curacins B and C, were isolated from a Curacao collection of Lyngbya majuscula. In addition, four curacin A analogs were prepared by semisynthetic methods. The structures of the new curacins and the curacin A analogs were determined by spectroscopic analysis in comparison with curacin A. The biological properties of the new natural products and synthetic derivatives of curacin A were examined. Investigations of another Curacao collection of L. majuscula revealed a new cytotoxic lipopeptide, microcolin C. Microcolin C was found to have an interesting profile of cytotoxicity to human cancer-derived cell lines. A new metabolite, vidalenolone, was isolated from an Indonesian red alga Vidalia sp. The structure of this new cyclopentenolone-containing compound was determined by a combination of spectroscopic methods. Filamentous cells isolated from female gametophytes of the brown alga Laminaria saccharina were cultured in flasks or bioreactors. These cultures produced a variety of usd\omega6usd-lipoxygenase metabolites: 13-hydroxy-9,11-octadecadienoic acid (13-HODE), 13-hydroxy-6,9,11,15-octadecatetraenoic acid (13-HODTA), and 15-hydroxy-5,8,11,13-eicosatetraenoic acid (15-HETE). Five oxidized anandamide derivatives were prepared from anandamide through autoxidation in an exploration of ligand binding to the cannabinoid receptor. Their structures were determined by a combination of NMR spectroscopy and GC-MS. The cannabinoid receptor binding affinity of these derivatives was evaluated. This study revealed the following trend in activity: anandamide > 15- > 9- > 8- > 11- > 5-hydroxyanandamide.

موضوع مستند نشده

curacin

موضوع مستند نشده

Health and environmental sciences

موضوع مستند نشده

Laminaria saccharina

موضوع مستند نشده

Lyngbya majuscula

موضوع مستند نشده

Pure sciences

موضوع مستند نشده

Vidalia

مستند نام اشخاص تاييد نشده

H.-D. Yoo

نام الکترونيکي

فرمت انتشار

p

نوع ماده

[Thesis]

کد کاربرگه

276903

سطح دسترسي

a

تكميل شده

Y