عنوان

Blood-Brain Barrier Permeability Changes after Subarachnoid Haemorrhage:

(Number (ISBN

3709161940

(Number (ISBN

9783709161944

Number

b587164

Title Proper

Blood-Brain Barrier Permeability Changes after Subarachnoid Haemorrhage:

General Material Designation

[Book]

Other Title Information

An Update : Clinical Implications, Experimental Findings, Challenges and Future Directions

First Statement of Responsibility

by Antonino F. Germanò, Francesco Tomasello.

Place of Publication, Distribution, etc.

Vienna

Name of Publisher, Distributor, etc.

Springer Vienna

Date of Publication, Distribution, etc.

2001

Specific Material Designation and Extent of Item

(x, 130 pages 41 illustrations)

Text of Note

The Concept of the BBB: A Historical Perspective --; Anatomy of the BBB --; Pathophysiology of BBB: Brain Oedema; Breakdown of the BBB --; BBB Dysfunction after SAH: Clinical Monitoring --; Neuroradiological Findings of BBB Dysfunction after SAH: Computerised Tomography and Magnetic Resonance SPECT and PET --; Experimental Data: Literature Review of BBB Dysfunction after Experimental SAH; Qualitative Assessments of BBB Dysfunction after SAH; Quantitative Assessments of BBB Dysfunction; Time Course of BBB Dysfunction after SAH; Additional Pathophysiological Changes after SAH --; Strategies for Pharmacological Intervention: Hydroxyl Radical Scavenger AVS; Glutamate Antagonist Felbamate; Calpain Inhibitor II --; Challenges and Future Direction: Advances in Cerebrovascular Pathophysiology; Gene Therapy.

Text of Note

This monograph constitutes a comprehensive overview of BBB permeability changes and related damaging sequelae asscociated with subarachnoid haemorrhage. Despite improvements in the surgical and clinical management patients still experience an unacceptably high morbidity and mortality linked to the presence of subarachnoid blood. In this monograph, the authors have reviewed the historical basis of this problem, the anatomical substrates of the BBB, the occurrence and adverse consequences of barrier disruption following SAH, the related sequelae of oedema formation, ICP alteration and vasospasm discussed from both the basic science and clinical perspective, with the consideration of multiple clinical and laboratory investigative tools, including all aspects of modern imaging. The text is supplemented by presenting key research publications in the field, focusing on the damaging consequences of subarachnoid blood, while attempting to explain the hierarchy of events in those progressive changes associated with blood-brain barrier perturbation, including vasospasm, ischaemia and elevated intracranial pressure.

Medicine.

Neurosciences.

Toxicology.

Class number

Book number

by Antonino F. Germanò, Francesco Tomasello.

Antonino F Germanò

Francesco Tomasello

Electronic name

[Book]

Y