History, Pathogenesis, Global Impact, Prevalence in Pakistan and Methods to Eradicate
Subsequent Statement of Responsibility
Moussavi, Mina
.PUBLICATION, DISTRIBUTION, ETC
Name of Publisher, Distributor, etc.
Boston University
Date of Publication, Distribution, etc.
2020
PHYSICAL DESCRIPTION
Specific Material Designation and Extent of Item
75
DISSERTATION (THESIS) NOTE
Dissertation or thesis details and type of degree
M.S.
Body granting the degree
Boston University
Text preceding or following the note
2020
SUMMARY OR ABSTRACT
Text of Note
By the 1950s, poliomyelitis (polio) was a major public health and medical issue as it became one of the most communicable diseases for children in the United States and globally. Following the widespread use of vaccinations in the 1950s, and an increased global effort in the late 1980s, cases of polio reduced exponentially in countries that were able to enroll widespread vaccination to their citizens. The elementary pathogenic process includes central nervous system (CNS) involvement which may lead to paralysis in extreme rare circumstances. Through mass-vaccination campaigns and global efforts led by the World Health Organization (WHO), United Nations Children's Fund (UNICEF), and the Bill & Melinda Gates Foundation, the number of new cases has remained minimal in most of the developed world except in three countries: Pakistan, Afghanistan, and Nigeria. There are multiple reasons why this disease continues to spread in these countries including vaccine-derived disease associated with mutations, geographical logistics, and the presence of anti-vaccine terrorist groups. While this review aims to explore the history, pathogenesis, and epidemiology of polio, a focus will also be placed on why the disease is still prevalent in Pakistan and novel methods that can be taken to ensure that polio is eradicated in the country. The goal should be for poliomyelitis to join the ranks of smallpox and rinderpest, the only two diseases that have ever been completely eradicated through the use of vaccinations and global cooperation.