عنوان

Blood-Brain Barrier Permeability Changes after Subarachnoid Haemorrhage:

شابک

3709161940

شابک

9783709161944

شماره

b587164

عنوان اصلي

Blood-Brain Barrier Permeability Changes after Subarachnoid Haemorrhage:

نام عام مواد

[Book]

ساير اطلاعات عنواني

An Update : Clinical Implications, Experimental Findings, Challenges and Future Directions

نام نخستين پديدآور

by Antonino F. Germanò, Francesco Tomasello.

محل نشرو پخش و غیره

Vienna

نام ناشر، پخش کننده و غيره

Springer Vienna

تاریخ نشرو بخش و غیره

2001

نام خاص و کميت اثر

(x, 130 pages 41 illustrations)

متن يادداشت

The Concept of the BBB: A Historical Perspective --; Anatomy of the BBB --; Pathophysiology of BBB: Brain Oedema; Breakdown of the BBB --; BBB Dysfunction after SAH: Clinical Monitoring --; Neuroradiological Findings of BBB Dysfunction after SAH: Computerised Tomography and Magnetic Resonance SPECT and PET --; Experimental Data: Literature Review of BBB Dysfunction after Experimental SAH; Qualitative Assessments of BBB Dysfunction after SAH; Quantitative Assessments of BBB Dysfunction; Time Course of BBB Dysfunction after SAH; Additional Pathophysiological Changes after SAH --; Strategies for Pharmacological Intervention: Hydroxyl Radical Scavenger AVS; Glutamate Antagonist Felbamate; Calpain Inhibitor II --; Challenges and Future Direction: Advances in Cerebrovascular Pathophysiology; Gene Therapy.

متن يادداشت

This monograph constitutes a comprehensive overview of BBB permeability changes and related damaging sequelae asscociated with subarachnoid haemorrhage. Despite improvements in the surgical and clinical management patients still experience an unacceptably high morbidity and mortality linked to the presence of subarachnoid blood. In this monograph, the authors have reviewed the historical basis of this problem, the anatomical substrates of the BBB, the occurrence and adverse consequences of barrier disruption following SAH, the related sequelae of oedema formation, ICP alteration and vasospasm discussed from both the basic science and clinical perspective, with the consideration of multiple clinical and laboratory investigative tools, including all aspects of modern imaging. The text is supplemented by presenting key research publications in the field, focusing on the damaging consequences of subarachnoid blood, while attempting to explain the hierarchy of events in those progressive changes associated with blood-brain barrier perturbation, including vasospasm, ischaemia and elevated intracranial pressure.

موضوع مستند نشده

Medicine.

موضوع مستند نشده

Neurosciences.

موضوع مستند نشده

Toxicology.

شماره رده

نشانه اثر

مستند نام اشخاص تاييد نشده

by Antonino F. Germanò, Francesco Tomasello.

مستند نام اشخاص تاييد نشده

Antonino F Germanò

مستند نام اشخاص تاييد نشده

Francesco Tomasello

نام الکترونيکي

نوع ماده

[Book]

تكميل شده

Y