Saliva and gingival crevicular fluid (GCF) are the main fluids in human mouths and this thesis has examined their dynamics and flow characteristics in four studies. The first study determined the pattern of oral mucosa wetness levels throughout the mouth in subjects with normal and reduced salivary flow rates. After swallowing, a film of residual saliva remains on mucosal surfaces and its thickness is easily and rapidly measured by utilizing a frying pan shaped filter paper strip (Sialopaper held against the mucosal surface for five seconds to collect the saliva; a Periotron 6000 micro-moisture meter is then used to measure the volume of saliva collected. Mucosal saliva thickness was calculated in microns. Subjects with low whole salivary flow (and complaint of oral dryness) (I) had residual saliva volume lower than subjects with normal saliva flow (and a complaint of dryness)(II) and normal saliva flow (and no complaint of dryness)(III). The patterns of mucosal wetness were the same for all three groups (posterior hard palate driest, posterior tongue wettest) with saliva film thinnest for I and thickest for III in all sites. In the second study hyposalivation was induced with the anti-sialogogue Robinul and the developing mucosal wetness pattern. It was determined that over the 150 minutes of the study, the mucosal wetness pattern that developed was the same as seen in the first study. Furthermore, observation of the GCF flow revealed that GCF was unaffected by the decreasing salivary flow. The third study, compared the ability of water and a citric acid stimulant Pro-Flow at different swallowing intervals to increase residual mucosal wetness, in the posterior palate, in subjects with low (Group I) and normal (Group II) salivary flow. Mucosal wetness increased with time after swallowing and Pro-Flow stimulation in Group II subjects and with Pro-Flow in the Group I. The final study sought to examine the dynamics of GCF flow. Using successively more rapid GCF sampling, in an attempt to deplete the sulcus, it was possible to demonstrate the rapid (and undepletable) refilling of the gingival sulcus. The rate of inflow ranged from 0.02 and 0.16 mul/mm/min of crevice for healthy and severely inflamed gingiva respectively. Combining these inflow values, with the measured length of the crevice throughout the mouth, the overall contribution of GCF to oral fluids is calculated to range from 1-50%.
موضوع (اسم عام یاعبارت اسمی عام)
موضوع مستند نشده
Dental care
موضوع مستند نشده
Health and environmental sciences
نام شخص به منزله سر شناسه - (مسئولیت معنوی درجه اول )