Biosynthesis and cellular actions of bioactive natural products
General Material Designation
[Thesis]
First Statement of Responsibility
Shogo Mori
Subsequent Statement of Responsibility
Watanabe, Coran M. H.
.PUBLICATION, DISTRIBUTION, ETC
Name of Publisher, Distributor, etc.
Texas A&M University
Date of Publication, Distribution, etc.
2015
PHYSICAL DESCRIPTION
Specific Material Designation and Extent of Item
193
GENERAL NOTES
Text of Note
Committee members: Barondeau, David P.; Begley, Tadhg P.; Reinhart, Gregory D.
NOTES PERTAINING TO PUBLICATION, DISTRIBUTION, ETC.
Text of Note
Place of publication: United States, Ann Arbor; ISBN=978-1-339-52557-0
DISSERTATION (THESIS) NOTE
Dissertation or thesis details and type of degree
Ph.D.
Discipline of degree
Chemistry
Body granting the degree
Texas A&M University
Text preceding or following the note
2015
SUMMARY OR ABSTRACT
Text of Note
The utilization of natural products as therapeutic agents has been an invaluable resource throughout medicinal history. Through the combined application of combinatorial biosynthesis, the modification of a natural product by engineered enzymes, and the isolation of new bioactive natural products, the discovery of new therapeutic agents may be achieved. This work shows the novel enzymatic interaction in the biosynthesis of a known therapeutic agent and the isolation of a new bioactive natural product.
TOPICAL NAME USED AS SUBJECT
Biochemistry
UNCONTROLLED SUBJECT TERMS
Subject Term
Pure sciences;Cyanobacteria;Macrolactone;Natural product;Nonribosomal peptide synthetase;Polyketide;Polyketide synthase;Streptomyces;Thioesterase